In-Vitro Toxicology Testing Market 2017
The global market for in-vitro toxicology testing was estimated at USD 10.8 billion in 2014. The market is projected to reach USD 19 billion by the end of 2020 at a CAGR of 9.8% during the forecast period 2014-2020.
Predictive in-vitro toxicology is the new cutting edge technology in biopharmaceutical research. It is considered one of the most significant steps in drug discovery. Predictive in-vitro toxicology is expected to improve the quality and quantity of drugs entering clinical studies. In addition, it improves the safety and efficiency of new compounds and allows compounds to be arranged early in the development process. Earlier and more lucrative identification of potential mechanisms that cause adverse drug reactions have significant potential for improving consequences in drug discovery.
The dominant players in this market are Agilent Technologies
Alere Inc.
Bio-Rad
Sigma-Aldrich
Catalent Pharma Solutions
Charles River Laboratories
Covance
Cyprotex
Eurofins Scientific Inc.
GE Healthcare
Thermo Fisher Scientific and Quest Diagnostics.
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Several industries require toxicity testing of their products. On the basis of end-users, the market is segmented into pharmaceutical industry, cosmetics and household products, chemicals industry and the food & beverages industry. Pharmaceutical industry has the largest market share. This is attributed to the adoption of in-vitro methods in the detection of toxic effects to curb drug development costs and initiatives such as AXLR8 program by the European Union.
Cosmetics is expected to be the fastest-growing industry in coming years with government support and amendment of European Union’s Cosmetics Directive, which has set forth a ban on the use of animals in testing for any toxic effects of beauty products.
Rapid technological advances, ban on the use of animals for testing and advances in toxicity testing protocols are the major factors driving the growth of the in-vitro toxicology testing market. On the other hand, stringent regulatory framework and the inability of in-vitro models to detect certain anomalies are the major challenges faced by the market.
The market for in-vitro toxicology testing is segmented on basis of technology, methods and applications.
Technology segment is sub-divided into High Throughput Screening (HTS), molecular imaging, cell culture, genomics, toxicogenomics, proteomics and metabolomics. In-vitro testing includes the following methods namely, cell-based assay, biochemical-based assay, in-silico-based and ex vivo-based methods.
The application segment is further categorized into acute systemic toxicity, dermal toxicity, ocular toxicity pharmacokinetics & metabolism, organ-specific toxicity, reproductive/developmental toxicity and others.
Based on geography, the market is segmented into North America, Europe, Asia-Pacific and Rest of the World. Currently, Europe is the largest market for in-vitro toxicology testing, owing to the high prevalence of cosmetic product testing and government support, followed by North America. Asia-Pacific is the fastest-growing region. The emerging countries in the region such as China and India are expected to register moderately high growth rates compared to previous years because of low development costs and increase in investments.
Several players in this market are trying to expand their product portfolio in order to compete in the global market. Top companies are expanding their growth in this market by acquiring other companies while few others are using acquisition as a market entry strategy.
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Table of Content:
- INTRODUCTION 1
1.1 REPORT DESCRIPTION 1
1.2 RESEARCH APPROACH AND METHODOLOGY 3
1.2.1 INTRODUCTION 3
1.2.2 RESEARCH DESIGN 4
2. KEY DELIVERABLES 5
3. EXECUTIVE SUMMARY 6
4. MARKET DYNAMICS 9
4.1 MARKET SEGMENTATION 9
4.2 MARKET DRIVERS 10
4.2.1 CONSENSUS AGAINST USING ANIMALS IN TESTING PROCEDURES 10
4.2.2 RAPID ADVANCES IN TECHNOLOGIES BOOSTING THE MARKET GROWTH 10
4.2.3 ADVANCES IN TOXICITY TESTING PROTOCOLS 10
4.3 MARKET RESTRAINTS 11
4.2.1 THE INABILITY OF IN-VITRO MODELS TO DETECT CERTAIN ANOMALIES 11
4.3.3 STRINGENT REGULATORY FRAMEWORK 11
4.3.2 LIMITATIONS OF IN-VITRO TOXICOLOGY TESTING 11
5. MARKET SEGMENTATION 12
5.1 BY END USER 12
5.1.1 PHARMACEUTICALS 12
5.1.2 FOOD INDUSTRY 14
5.1.3 CHEMICALS INDUSTRY 15
5.1.4 COSMETICS 16
5.1.5 DIAGNOSTICS 17
5.1.6 OTHERS 18
5.2 BY MODE OF ADMINISTRATION 19
5.2.1 DERMAL 19
5.2.2 ORAL 20
5.2.3 OCCULAR 20
5.2.4 INHALATION 21
5.2.5 INFUSION 21
5.2.6 RECTAL ADMINISTRATION 22
5.2.7 PARENTERAL ADMINISTRATION 22
5.2.8 INTRA-ARTERIAL ADMINISTRATION 23
5.2.9 INTRA-NASAL ADMINISTRATION 23
5.3 BY TECHNOLOGY 24
5.3.1 HIGH-THROUGH PUT SCREENING 24
5.3.2 MOLECULAR IMAGING 26
5.3.3 CELL CULTURE 27
5.3.4 OMICS 28
5.3.4.1 GENOMICS 28
5.3.4.2 TOXICOGENOMICS 29
5.3.4.3 PROTEOMICS 30
5.3.4.4 METABOLOMICS 31
5.3.4.5 OTHERS 32
5.4 BY METHOD 33
5.4.1 CELL-BASED ASSAY 33
5.4.2 BIOCHEMICAL-BASED ASSAY 34
5.4.3 IN-SILICO-BASED 35
5.4.4 EX VIVO-BASED METHODS 36
5.4.5 OTHERS 37
- COMPANY PROFILES 87
7.1 SIGMA-ALDRICH FINE CHEMICALS 87
7.1.1 BUSINESS OVERVIEW: 87
7.1.1 PRODUCTS & SERVICES: 87
7.1.1 FINANCIALS: 88
7.2 BIOVIA CORPORATION 89
7.2.1 BUSINESS OVERVIEW: 89
7.2.2 PRODUCTS & SERVICES 89
7.3 AGILENT TECHNOLOGIES 90
7.3.1 BUSINESS OVERVIEW: 90
7.3.1 PRODUCTS & SERVICES: 90
7.3.1 FINANCIALS: 90
7.4 CHARLES RIVER LABORATORIES 91
7.4.1 BUSINESS OVERVIEW 91
7.4.2 PRODUCTS & SERVICES 91
7.4.3 FINANCIALS 92
7.5 COVANCE INCORPORATED 93
7.5.1 BUSINESS OVERVIEW 93
7.5.2 PRODUCTS & SERVICES 93
7.5.3 FINANCIALS 93
7.6 GE HEALTHCARE 94
7.6.1 BUSINESS OVERVIEW 94
7.6.2 PRODUCTS & SERVICES 94
7.6.3 FINANCIALS 94
7.7 THERMO FISHER SCIENTIFIC INC. 95
7.7.1 BUSINESS OVERVIEW: 95
7.7.2 PRODUCTS AND SERVICES: 95
7.7.3 FINANCIALS: 96
7.8 QUEST DIAGNOSTICS INC. 97
7.8.1 BUSINESS OVERVIEW: 97
7.8.2 PRODUCTS AND SERVICES: 97
7.8.3 FINANCIALS: 97
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